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methylprednisolone will lower the level or outcome of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.Lonafarnib may possibly enhance the AUC and peak concentration of CYP2C19 substrates. If coadministration unavoidable, keep track of for adverse reactions and decrease the CYP2C19 substrate dose in accordance